| ncRNA name | dre-miR-223 |
| ncRNA Category | miRNA |
| Disease name | optic nerve injury |
| Species | Danio rerio |
| Tissues/Cell_line | retinas |
| Methods | microarray, qRT-PCR, transfection, luciferase reporter assay |
| Expression pattern | up-regulated |
| Functional description | We focused on two over-expressed miRNAs (miR-29b and miR-223), and functionally validated seven of their predicted gene targets using RT-qPCR and luciferase assays to confirm miRNA-mRNA binding. Gene ontology analysis placed the miRNA-regulated genes in key biological processes that included cell survival/apoptosis, ECM-cytoskeleton signaling, and heparan sulfate proteoglycan binding. |
| PubMed ID | 26265132 |
| Year | 2015 |
| Title | Integrated analyses of zebrafish miRNA and mRNA expression profiles identify miR-29b and miR-223 as potential regulators of optic nerve regeneration. |
| Drug-related ncRNA | NO |
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